MAOIs act oxidase inhibition, which is a complex enzyme system which metabolizes serotonin and adrenaline overload. Has the ability to make a vital negative problems, and therefore can not be used in patients who suffer from congestive heart failure or who have a history of liver disease. Can be dangerous for those who have hypersensitivity to its components. It should be used only when other antidepressants fail treatment options available to treat depression.
ATC law in the first place by the inhibition of reuptake of serotonin and norepinephrine. Although the type of side effects experienced by the patient because TCAS or MAOIs are often similar, and the frequency of side effects is much lower in the case of tricyclic antidepressants. Thus, TCAS enjoy better acceptance rate by patients.
SSRIs law by serotonin reuptake inhibition, and is considered the most popular drugs are safe and effective. Enjoyed Prozac, a drug of this class, a great success in the treatment of depression and suicide prevention. To have fewer side effects compared with tricyclic antidepressants and MAOIs, and well tolerated.
It is important to note that these three groups therapeutic post similar to relieve the symptoms of depression in the same period of time (1-4 weeks). SSRIs, because of their interest in the safety and tolerability, and enjoy the first-line position. Tricyclic antidepressants are much less expensive than SSRIs and they are preferred by patients who do not respond to other antidepressants.
SNRIs better service for the patient to keep depression serotonin and noradrenaline at the appropriate level. Bupropion (novel antidepressant) is unique in its effectiveness to prevent the absorption of serotonin, dopamine and norepinephrine.
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